The present study sought to predict marital satisfaction, hypothesizing that it would be best predicted by self-efficacy, self-esteem, and job satisfaction, measured among non-medical healthcare staff. The research design that was applied was of a descriptive-correlational nature. The statistical population from which the data were drawn consisted of non-medical staff working in hospitals in Tehran province in the year 2023. A total of 196 participants were selected using convenience sampling. Data collection was conducted using the ENRICH Marital Satisfaction (EMS) Scale, the Minnesota Satisfaction Questionnaire (MSQ), the General Self-Efficacy Scale (GSE), and the Rosenberg Self-Esteem Scale (RSES). The results indicated a positive and significant relationship between self-efficacy, self-esteem, and job satisfaction with marital satisfaction (P < 0.01). These variables were able to predict 39% of the variance in marital satisfaction. It can be concluded that self-efficacy, self-esteem, and job satisfaction are capable of predicting marital satisfaction among non-medical healthcare staff. Therefore, it is suggested that family psychologists focus on enhancing self-efficacy, self-esteem, and job satisfaction in their planning to improve marital satisfaction among couples.